Program

PROGRAM UPDATE 26-JUL-2019 (Almost there, subject to minor changes)

SUNDAY 4-AUG-2019

VENUE: TAMPERE HALL
17:00 Registration opens
18:00 Get-together party


MONDAY 5-AUG-2019 (Philips Day)

08:15 Welcome Olli Polo, MD, PhD, Conference Chair

CONTROL OF BREATHING 1: CENTRAL REGULATION AND LINKS TO METABOLISM
Chairs: Virend Somers, Rochester, USA and Olli Polo, Tampere, Finland

08:30 – 09:15 KEY NOTE SPEAKER
Patrice G. Guyenet, BS, PhD, University of Virginia, Charlottesville, USA
RTN: Central respiratory chemoreceptor and regulator of breathing automaticity

09:15 – 09:30 Pisanski et al. (Abstract 01)
Chemogenetic modulation of the parafacial respiratory group influences the recruitment of abdominal activity during REM sleep

09:30 – 10:15 KEY NOTE SPEAKER
Silvia V Conde, PhD, New University of Lisbon, PORTUGAL Carotid body, insulin, and metabolic diseases: unraveling the links

10:15-10:30 COFFEE BREAK

METABOLIC ASPECTS OF SLEEP-DISORDERED BREATHING
Chairs: Vsevolod (Seva) Polotsky, Baltimore, USA and Tarja Saaresranta, Turku, FINLAND

10:30 -11:15 KEY NOTE SPEAKER
Matthew Naughton, Alfred Hospital, Monash University, Melbourne, AUSTRALIA
Obesity and weight loss

11:15 -11:35 Vsevolod (Seva) Polotsky, Baltimore, USA (Abstract 02)
Leptin Resistance and Sleep-Disordered Breathing: Where is the chicken? Where is the egg?

11:35 – 11:55 Naima Covassin, Rochester, USA (Abstract 03)
Insufficient sleep and cardiometabolic disease or Sleep Deprivation and Hypertension

11:55 – 12:15 Jean-Louis Pepin, Grenoble, FRANCE
Sleep apnea and non-alcoholic fatty liver disease (NAFLD)

12:15 – 13:15 LUNCH AND POSTER VIEWING (Posters 36-40)

  • Dickson et al. Limited effects of breathing hyperoxic gas on sleep structure during midday naps in human subjects (Abstract 36)
  • Epiu et al. Responses to airway occlusion in inspiratory muscles of Chronic Obstructive Pulmonary Disease and healthy age-matched controls (Abstract 37)
  • Grivell et al. Sleep health management within primary care: An Interpretive Description of the knowledge, experiences and attitudes of practice nurses (Abstract 38)
  • Huhtakangas et al. Stroke Volume Predicts Nocturnal Hypoxemia in the Acute Ischemic Stroke after Intravenous Thrombolysis (Abstract 39)
  • Kainulainen et al. Differentiating sleepy and non-sleepy OSA patients using nocturnal pulse oximetry and deep learning (Abstract 40)

ORAL SESSION I: CLINICAL, METABOLIC
Chairs: Naima Covassin, Rochester, USA and Ulla Anttalainen, Turku, FINLAND

13:15 – 13:30 Marcouiller et al. (Abstract 04)
Sex-specific metabolic consequences of intermittent hypoxia mediated by estradiol in mice.

13:30 -13:45 Aro et al. (Abstract 05)
Gender-specific change in leptin concentrations during long-term CPAP therapy

13:45 – 14:00 Gu et al. (Abstract 06)
Effect of Dinner Timing on Nocturnal Metabolism in Healthy Volunteers.

14:00-14:15 Chasens et al. (Abstract 07)
Nighttime Sleep and Daytime Function in Type 2 Diabetes and Obstructive Sleep Apnea: The Effect of CPAP

14:15-14:30 Baniak et al. (Abstract 08)
The Effect of CPAP Use on Insomnia Among Persons with Type 2 Diabetes and Obstructive Sleep Apnea

14:30 -14:45 COFFEE BREAK

SPONSOR´S SESSION organized by Philips
Chairs: David P. White, Denver, USA and Mary Ip, Hong Kong, CHINA

14:45-15:15 David P. White
The sleep disorder analyzer and sleep ecosystem

15:15-15:45 Jean-Louis Pépin
Positional obstructive sleep apnea : epidemiology and treatment

15:45-16:15 Brady A. Riedner
The function of slow wave sleep and its enhancement

16:15-16:30 COFFEE BREAK

ORAL SESSION II
Chairs: Thomas Penzel, Berlin, GERMANY and Ville Rimpilä, Tampere, Finland

16:30-16:45 Osman et al. (Abstract 09)
Major changes in pharyngeal collapsibility and genioglossus reflex responses to negative pressure throughout the respiratory cycle in obstructive sleep apnoea

16:45-17:00 Luu et al. (Abstract 10)
Genioglossus motor unit activity in supine and upright postures in obstructive sleep apnoea

17:00-17:15 AlMarabeh et al. (Abstract 11)
Blunted diuretic response to volume expansion with preserved low-pressure baroreflex function in rats exposed to chronic intermittent hypoxia

17:15-17:30 Greenlund et al. (Abstract 12)
Alpha Intrusion during Rapid Eye Movement (REM) and K Complexes in Stage Two Sleep Increase Beat-to-Beat Blood Pressure in Humans

17:30 – 17:45 Newitt et al. (Abstract 13)
The Impact of REM-AHI on Revascularized Cardiac Patients

18:15 DEPARTURE FOR DINNER and SAUNA at Viikinsaari Island https://visittampere.fi/en/venues/viikinsaari/viikinsaari-sauna/


TUESDAY 6-AUG-2019 (ResMed Day)

CONTROL OF BREATHING 2: THE CAROTID BODY
Chairs: Indu Ayappa, New York, USA and Ingo Fietze, Berlin, Germany

08:15 – 08:45 KEY NOTE SPEAKER
Jose Lopez-Barneo, Sevilla, SPAIN
Carotid body acute oxygen sensing and regulation of breathing

08:45 – 09:30 KEY NOTE SPEAKER
Nanduri Prabhakar DSc, PhD, University of Chicago, Chicago, USA
Carotid body chemoreflex and sleep apnea

09:30-09:45 COFFEE BREAK

ORAL SESSION III (CLINICAL): PREDICTION AND TREATMENT OF SLEEP APNEA
Chairs: Zou Ding, Gothenburg, SWEDEN and Adel Bachour, Helsinki, Finland

09:45 -10:30 KEY NOTE SPEAKER
Vsevolod (Seva) Polotsky, Baltimore, USA
Pharmacotherapy of Obstructive Sleep Apnea: where we are now and where we are going

10:30 -10:45 Aishah et al. Effects of atomoxetine combined with different anti-muscarinics on OSA severity and upper airway physiology (Abstract 14)

10:45 – 11:00 Laharnar et al. Adaptation and validation of a new morphologic OSA prediction score – Results of SAGIC (Abstract 15)

11:00 – 11:15 Myllylä et al. Motor vehicle accidents in continuous positive airway pressure adherent obstructive sleep apnea patients – a retrospective observational study (Abstract 16)

11:15-11:30 Khadadah et al. Obstructive sleep apnea treatment of multiple sclerosis patients with severe fatigue using positive airway pressure (SAMS-PAP trial): initial study results. (Abstract 17)

11:30 -11:45 Herculano et al. The Role of Fluid Retention in Acute Weight Gain During CPAP Treatment in Patients with Obstructive Sleep Apnea (Abstract 18)

11:45 – 12:00 Sériès et al. CPAP therapy is not needed in every obese sleep apnea patient awaiting bariatric surgery: results of a 813 patients cohort study (Abstract 19)

12:00 -12:15 Li et al. Differences in predicted therapeutic outcome of mandibular advancement determined by Remotely Controlled Mandibular Positioner in Caucasians and Chinese apneic patients. (Abstract 20)

12:15-12:30 Xu et al. Incident hypertension in obstructive sleep apnoea and effect of continuous positive airway pressure treatment: A retrospective clinic cohort study (Abstract 21)

12:30 – 13:15 LUNCH AND POSTER VIEWING (Posters 41-45)

  • Kalevo et al. Improved Sweat Artifact Tolerance of Screen-Printed Electrodes by Material Selection – In vivo Comparison of the EEG Signal Quality (Abstract 41)
  • Korkalainen et al. (presented by Timo Leppänen) Deep Learning Enables Accurate Sleep Staging Based on a Single Frontal EEG Channel (Abstract 42)
  • Leino et al. Neural network analysis of nocturnal SpO2 signal enables easy screening of sleep apnea in acute stroke and transient ischemic attack patients (Abstract 43)
  • Nguyen et al. Electromyographic activity in the human costal and crural diaphragm during voluntary and involuntary breaths (Abstract 44)
  • Nikkonen et al. Artificial neural network analysis of oxygen saturation signal enables accurate automatic screening of sleep apnea (Abstract 45)

PHENOTYPING OF SLEEP APNEA
Chairs: Jan Hedner, Gothenburg, SWEDEN and Walter McNicholas, Dublin, Ireland

13:15 – 14:00 KEY NOTE SPEAKER
Danny Eckert, Sydney, AUSTRALIA
Sleep Apnea phenotypes

14:00-14:15 Laharnar et al. Pulse wave analysis and autonomic differences in insomnia phenotypes (Abstract 22)

EUROPEAN SLEEP APNEA DATABASE (ESADA) SESSION

14:15-14:30 Walter McNicholas, Dublin
The European Sleep Apnea Database (ESADA) Project. A successful European collaboration.

14:30-14:45 Herberger et al.
Unique sleep stage transition patterns determined by obstructive sleep apnea severity, age and gender – Results of ESADA (Abstract 23)

14:45 – 15:00 Izolde Bouloukaki, Crete
Mild OSA and Arterial Hypertension in the European Sleep Apnea Database cohort study.

15:00 – 15:15 Zou Ding, Gothenburg
An unexpected association: Hypertension in OSA related to HCO3 concentration.

15:15-15:30 Athanasia Pataka, Greece
OSA and Cancer

16:00 – SOCIAL EVENT (Bus transfer to Serlachius Museums, Mänttä)
http://www.serlachius.fi/en/our-museums/

Evening banquette with music and dance


WEDNESDAY 7-AUG-2019 (Fischer-Paykel Day)

AROUSAL MECHANISMS
Chairs: John Kimoff, Montreal, CANADA and David Rapoport, New York, USA

08:15-09:00 KEY NOTE SPEAKER
Clifford B. Saper, MD, PhD, Harvard Medical School, Boston, USA
A brain circuit for arousal during apnea

09:00 – 09:45 KEY NOTE SPEAKER
Matthew Naughton, Alfred Hospital, Monash University, Melbourne, AUSTRALIA
Sleep-disordered breathing in chronic heart failure (CHF)

09:45 – 10:00 Palman et al. Cheyne-Stokes respiration in patients with chronic heart failure and its treatment with acetazolamide: a pilot study (Abstract 24)

10:00 – 10:15 COFFEE BREAK

NEURAL DRIVES AND BREATHING
Chairs: Winfried Randerath, Solingen, GERMANY and Sari-Leena Himanen, Tampere, FINLAND

10:15 – 10:30 Nguyen et al. presented by Jane Butler. Increased neural respiratory drive to the diaphragm during quiet breathing in tetraplegia (Abstract 25)

10:30 – 10:45 Nguyen et al. presented by Anna Hudson. Neural respiratory drive during quiet breathing does not have a cortical component in tetraplegia (Abstract 26)

10:45 – 11:00 Agarval et al. Prediction of Acute Blood Pressure Response to Obstructive Apneas and Hypopneas Using Routine Polysomnography Data (Abstract 27)

11:00 – 11:15 Partinen et al. Sleep apnea as risk factor of driving accidents in professional truck drivers: A 14-year prospective study (Abstract 28)

BEYOND AHI

11:15 – 11:30 Rimpilä et al.
Transcutaneous carbon dioxide during sleep-disordered breathing (Abstract 29)

11:30 – 11:45 Polo et al.
Principles and practice of transcutaneous pCO2 measurement during sleep (Abstract 30)

11:45 – 12:00 Rapoport et al. Beyond the AHI – Using Breath-by-Breath Flow Amplitude to Quantitate Severity of OSA. (Abstract 31)

11:45-13:00 LUNCH and POSTER VIEWING (Posters 46-49)

  • Polo et al. Modeling Sympathetic Tone and Phasic Events During Sleep with Transcutaneous Carbon Dioxide Measurement (Abstract 46)
  • Song et al. Effect of Repetitive Acute Hypoxic Preconditioning on Airway Reactivity during House Dust Mite – Induced Allergic Inflammation (Abstract 47)
  • Souza et al. Interactions between Obstructive Sleep Apnea and Sleep Duration with Subclinical Atherosclerosis Evaluated by Coronary Calcium Score: Cross-sectional Data from ELSA-Brasil study (Abstract 48)
  • Souza, G.M.P.R., Stornetta, R.L., Stornetta, D.S., Abbott, S.B.G. Guyenet, P.G. Contribution of retrotrapezoid nuleus and carotid bodies to arousal elicited by hypoxia and hypercapnia in rats (Poster 49)
  • Sowho et al. Noise Pollution in the Bedroom (Abstract 50)

ORAL SESSION IV
Chairs: Frédéric Sériès, Quebec, CANADA and Olli Polo, Tampere, FINLAND

13:00-13:15 Curado et al.
Humanized Chemogenetic Approach to Treat Sleep Apnea (Abstract 32)

13:15- 13:30 Cunningham et al.
Total Sleep Deprivation and Pain Perception during Cold Noxious Stimuli in Older Adults (Abstract 33)

13:30 – 13:45 Kam et al.
Impaired recall of spatial navigation in cognitively normal older individuals with obstructive sleep apnea (Abstract 34)

13:45-14:00 Utriainen et al.
Sleep apnea in peripheral atherosclerosis (Abstract 35)

14:00 – 14:30 Olli Polo:
“Imagination is more important than knowledge” (Albert Einstein) – Drawing an image from the zigsaw pieces of sleep-disordered breathing

14:45-16:00 FAREWELL PARTY WITH STRAWBERRIES – HAVE A SAFE TRAVEL BACK HOME

POSTERS

Dickson et al. Limited effects of breathing hyperoxic gas on sleep structure during midday naps in human subjects (Abstract 36)

Epiu et al. Responses to airway occlusion in inspiratory muscles of Chronic Obstructive Pulmonary Disease and healthy age-matched controls (Abstract 37)

Grivell et al. Sleep health management within primary care: An Interpretive Description of the knowledge, experiences and attitudes of practice nurses (Abstract 38)

Huhtakangas et al. Stroke Volume Predicts Nocturnal Hypoxemia in the Acute Ischemic Stroke after Intravenous Thrombolysis (Abstract 39)

Kainulainen et al. Differentiating sleepy and non-sleepy OSA patients using nocturnal pulse oximetry and deep learning (Abstract 40)

Kalevo et al. Improved Sweat Artifact Tolerance of Screen-Printed Electrodes by Material Selection – In vivo Comparison of the EEG Signal Quality (Abstract 41)

Korkalainen et al. (presented by Timo Leppänen) Deep Learning Enables Accurate Sleep Staging Based on a Single Frontal EEG Channel (Abstract 42)

Leino et al. Neural network analysis of nocturnal SpO2 signal enables easy screening of sleep apnea in acute stroke and trancient ischemic attack patients (Abstract 43)

Nguyen et al. Electromyographic activity in the human costal and crural diaphragm during voluntary and involuntary breaths (Abstract 44)

Nikkonen et al. Artificial neural network analysis of oxygen saturation signal enables accurate automatic screening of sleep apnea (Abstract 45)

Polo et al. Modeling Sympathetic Tone and Phasic Events During Sleep with Transcutaneous Carbon Dioxide Measurement (Abstract 46)

Song et al. Effect of Repetitive Acute Hypoxic Preconditioning on Airway Reactivity during House Dust Mite – Induced Allergic Inflammation (Abstract 47)

Souza et al. Interactions between Obstructive Sleep Apnea and Sleep Duration with Subclinical Atherosclerosis Evaluated by Coronary Calcium Score: Cross-sectional Data from ELSA-Brasil study (Abstract 48)

Souza, G.M.P.R., Stornetta, R.L., Stornetta, D.S., Abbott, S.B.G. Guyenet, P.G. Contribution of retrotrapezoid nuleus and carotid bodies to arousal elicited by hypoxia and hypercapnia in rats (Poster 49)

Sowho et al. Noise Pollution in the Bedroom (Abstract 50)

Gharraf et al. Study of Leptin and Ghrelin Serum Levels in Patients with Obstructive Sleep Apnea (Abstract 51)

Gharraf et al. Comparison between the use of APAP and manual titration during split night polysomnography for diagnosis and treatment of OSA (Abstract 52)

Gharraf et al. Correlation of cardiopulmonary exercise testing parameters with BODE index in stable COPD patients (Abstract 53)